looking at the intermediate laboratory variables is one way to look at the studies, in epidemiology, we like to look at what happened humans as opposed to pieces of the immunologic systems, but there are other studies that are on the other side of this that says that the j&j vaccine is equally effective. maybe it is, maybe it isn't. maybe at some point in the future, the cdc may recommend that people with j&j vaccine get an mrna booster, but that's not happening yet. >> meaning the fars they are or moderna, right? one-shot and not two shots? >> who knows what they will imagine. in europe, that where they have used another vaccine that is similar to the johnson & johnson vaccine in that it uses the adenovirus to get the genetic code into the cells, there is frequently, because they ran really low on the astrazeneca vaccine, they frequently, the people get the second dose with an mrna vaccine, including last week, merkel got her second vaccine. so, it is really common usage there. >> so, we do not you know yet if the cdc will make that recommendation, but your question here from bath.