institute with our laboratory. it was a very long period of time. we were held studies first on experimental animals. this is, of course, the white laboratory rat of our vivarium. institute of physiology diabetes mellitus particular research. this issue was covered somewhere. well, about four years to conclude. at stages e, we looked at some laboratory parameters and blood cells of already patients who have been verified, that is , diagnosed with diabetes mellitus , in cooperation with clinicians, the main conclusions, the most important very first target that takes a hit in diabetes diabetes. this is me brain weight. that is, it was the vessels of the microvasculature of the brain and the brain tissue that were damaged in the first place. e, ultrastructures of endothelial cells, that is, those cells that line inside e, vessels of blood growth frontal lobes. and changes in platelets were expressed, that is, they were prone to increased aggregation. that is, they accumulated together formed such conglomerates and pronounced changes in red blood cells, that is, erythrocytes. and when we examined the erythrocytes of experimental animals. it was a very pronounced picture, that is, all the erythrocytes were