gene therapy there are about 700 gene therapy trials in the u.s. andagency told me about 700 them are expanded access trials that can involve a single person. that is a method people are using to pay to getting therapy now. host: let's get to daniel in pennsylvania. hey, daniel. caller: good morning. saying that we are actually socializing the development of these treatments, and then prioritizing the distribution. natural resourcesona where we use blood and treasure to get access and then privatizers distribution. am i correct in that assumption? thank you. host: thank you, daniel. guest: i thank you are. aul mentions the case in florida. there was one boy treated for canavan disease, due to extended access protocol, so the family paid more than $1.5 million. it seems to have gone well. not cause any ill effects are suddenly, biotech companies are very interested in that and have formed a company to advance it. the national institutes of health, the government, families, pay to get this to the research where principles improve, and then private in

me take it genes which can cause diseases for example can be completely switched off. genes can not only because out but they can also be repaired or even replaced. the for. using the technology on human embryos however has so far been taboo not all research is feel bound by these ethical traditions for some it may be more important to prove they are at the forefront of gene therapy technology by an experimental and it is a false in my opinion this represents a reckless human experiment and neither the risks nor the benefits have been properly established society hasn't been consulted me it's medically not necessary the whole thing was announced a day before a major international summit on the topic as a provocation incest and for cats. the case has also caused an uproar in china more than one hundred scientists have signed an open letter denouncing it as risky and unjustified adding that it hummed the reputation and development of the by medical community in china. let's get more. data science welcome but terry let's start with the claim it's not been verified how sur

gene then you won't get it now but the problem is is that genes don't really work that way it's very very rarely one gene for one particular process and by removing this particular gene he might have condemned these babies to actually other possibly difficult genetic circumstances not only that the crisper cast nine technology that's that that's the protein that we just saw in the piece it's called chris protected cats nine this technology is very very precise but it's not perfect and so they're also what they call off target effects now and off target effect means that that particular technology that particular enzyme could also alter the genome in other places not just in the place where the doctor or where this. searcher claims that he did his work so the claim that the babies are perfectly healthy and that everything is just fine with them actually he can't really make that claim and despite all these concerns the scientists say as we could not report if not me someone else would have done it is the right tool has he crossed a fundamental ethical boundary. yes he is right in the

took out a gene that enables h. i.v. to get into the body the cells if you're exposed to be with that same gene could be involved let's say in the proper functioning of the brain or the liver or the heart and so other one of the concerns with this technology is that if we take out a particular gene because we think it may be involved in a particular disease or our function might that gene have other functions that we don't yet fully understand that may lead to problems in the child and so you also want to see that these are healthy kids for instance that they are in otherwise every all systems are go just to come to canceling sorry i want to get one more question to you before we have to move on and that's just about obviously the flip side the negative side regulation would have to be absolutely if down the road this was found to be something viable and otherwise you just get people making all sorts of choices by themselves. yes exactly so you do need to be careful regulation careful oversight he did not publish it

most of his team now works with genes his is developing new approaches for gene therapy. the humans interact he shares was we missing a technology to act on the d.n.a. in a precise fashion and this is what chris pakistan brings now there is out to bring this technology to the right says and he shoots to cure and he says where we see a lot of developments happening. for me it really is a dream come true for the first time because it gives us a way to change the genome in human cells in a targeted way that opens up infinite possibilities that's what we want to do here in fiber book is developing new therapy options for patients with immune deficiencies and hiv patients. i think this is a sharing in a second green revolution of the first one used traditional plant breeding techniques and was able to increase yields all over the world i think this will trigger a second green revolution revenue to. curing dangerous diseases overcoming hunger with better crops crisper researches have ambitious plans. are you compassionate and thoughtful or ruthless and criminal. are good and ba

genes can not only because it out but they can also be repaired or even replaced. using the technology on human embryos however has so far been taboo not all research is feel bound by these ethical traditions for some it may be more important to prove they are at the forefront of gene therapy technology. i mix i meant and it is the house in my opinion this represents a reckless human experiment. neither the risks nor the benefits of being properly established society hasn't been consulted it's medically not necessary the whole thing was announced a day before a major international summit on the topic it's a provocation and. the case has also caused an uproar in china more than one hundred scientists have signed an open letter denouncing it as risky and unjustified adding that it hummed the reputation and development of the by medical community in china. so is it ok to use gene editing tools like this to modify unborn children and stop them from developing genetic diseases well that's the question that we put to a science is from the innovative genero weeks institut

the gene is removed and replaced with a different gene. he manipulated the genes to make them resistant to hiv. then their mother using in vitro. >> no gene was changed but the one to prevent hiv. the girls are safe, healthy babies. >> reporter: he warned this man, a uc berkeley. >> to fix the mutation that causes a disease. stat reported that he told no one but his response at the time was unmistakable. don't do it. >> i think it was irresponsible. >> reporter: a professor of medicine at the university of pennsylvania reviewed the data and believes the edits are incomplete and the girls may not be immune to hiv after all. he worries the process may have left the twins susceptible to t children to me it is absolutely appalling and horrifying. >> reporter: at the human geno editing summit in hong kong hours ago, he spoke about his findings and what comes next. >> and the plan to monitor the twins health for the next 18 years with the hope that the baby consent as adult for continued monitoring and support. >> one of the coinventors is a pro

is there such a thing as a criminal gene. from kleptomania. serial killers for centuries people have been researching factors behind criminal behavior environmental and social causes or perhaps even genetic makeup. but the criminal gene question raises a range of moral issues the nazi era is a case in point the nazis exploited dubious notions of genetically inferior criminals with inborn characteristics to justify persecution and genocide. new studies however suggest that some gene variants may be connected to aggressive behavior. notorious serial killer charles manson had a mother and uncle who are criminals is that significant. it seems that what our genes influence is not our character but chemicals in the brain violent people may have lower levels of the neurotransmitter serotonin to little sever tone in the brain can lead to uncontrolled aggression. damage to the frontal lobe of the brain can also make people more volatile one famous case is the american railroad worker phineas gage in one thousand nine hundred eighty eight an explosion d

is this a breach of medical ethics, editing the genes of embrs?l, it is one of the most significant experiments in the history of human genetics to change genes in our children, and it is stupendously unethical to have done so given where the technology is today. laura: is gene editing technology something that could very easily be misused? dr. caplan: gene editingch logy has been misused. this gentleman has misused it. he basically acted like a moral putz, meaning a moral idiot. he did not get approval from thm scientificnity, who does not yetelieve that the gene editing technique is ready for use this way. there has not been enough experimentation on animal embryos or human embryos in dishes to know that it is accurate and reliable. he did it in secret. he actually published and ethics paper, believe it or not, in whiche failed to disclose he was doing this experiment. he has been secretive. he has been talking about it only on youtube. he has never shared in writing what he has done. he is using a technique that scientificag cols don't approve

gene therapy there are about 700 gene therapy trials in the u.s.ndagency told me about 700 them are expanded access trials that can involve a single person. that is a method people are using to pay to getting therapy now. host: let's get to daniel in pennsylvania. hey, daniel. caller: good morning. saying that we are actually socializing the development of these treatments, and then prioritizing the distribution. natural resourcesona where we use blood and treasure to get access and then privatizers distribution. am i correct in that assumption? thank you. host: thank you, daniel. guest: i thank you are. aul mentions the case in florida. there was one boy treated for canavan disease, due to extended access protocol, so the family paid more than $1.5 million. it seems to have gone well. not cause any ill effects are suddenly, biotech companies are very interested in that and have formed a company to advance it. the national institutes of health, the government, families, pay to get this to the research where principles improve, and then private indu

took out a gene that enables h. i.v. to get into the body cells if you're exposed hiv but that same gene could be involved let's say in the proper functioning of the brain or the liver or the heart and so other one of the concerns with this technology is that if we take out a particular gene because we think it may be involved in a particular disease or or function might that gene have other functions that we don't yet fully understand that may lead to problems in the child now south asia's first fully digitized restaurant has opened in a pool locally made robots named ginger and now serving customers at this cafe and kaplan do a local tech company develop the robots to essentially design in china japan. the best of all time in the school. welcome back now the un's environment body has found the world needs to do three times what it's currently doing to avoid catastrophic climate change the twenty fifteen paris climate deal agreed to limit the rise in global temperatures to a maximum of two degrees celsius this cent

laura: is gene editing technology somethi that could very easily be misused? dr.: gene editing technology has been misused. this gentleman has misused it. he basically acted like a moral putz, meaning a moral idio he did not get approval from the scientific community, who doesye no believe that the gene editing technique is ready for use this way. there has not been enough experimentation on animal embryos or human embryos in dies to know that it is accurate and reliable. he did it in syret. he actua published and ethics paper, believe it or not, in which he failed to disclose he was doing this experiment. he has been secretive. he has been talking about it only on youtube. he has never shared in writing what he has ne. he is using a technique that scientific colleagues don't approve of. by the way, he has a conflict of interest. he has applied for pheents and s clearly bringing people to the infertility clinic at some significant fee to try thi technology out on them. normally you would not let ape on who is trying to recruit people to this novel approach bw the

in those cases and creating gene edited babies?tting out bad genes and putting in newjeans. you can try to fix the problem in a person who has the disease, if you have cystic fibrosis, or you have theseis have cystic fibrosis, or you have these is in the eye that are causing you to go blind, you try to sniff out the bad genes, put in the good ones and see if it will grow and repair. that is not passed on to future generations. what the experiment that took place in china did was to say we're going change genes in embryos and they will affect children and their descendents, that's called gene that line engineering and that's a whole other step first of all we have not done much of that or consecutive of all there is no ability to consent to it by children yet to come. to be clear it's a whole other is that because we don't yet know what the risks associated with this would be? correct. you might say i'm going to try and do an experiment in a person to see if i can fix cystic fibrosis cells that are wrong and if it doesn't work we st

gene moran from opa-locka county, let's check that out. gene, hi. gene, gene? can you hear me?y: it's jimmy kimmel, gene. sorry to interrupt you. i see you're counting votes there. >> yes, jimmy, 24/7. 985425, 985426 -- and thank goodness may i say for crack cocaine and sunny d. [ laughter ] i am wired to the gills right now. >> jimmy: well, you look great. you're counting all those votes by hand? i thought they were doing a machine count. >> machine count? i am the machine. [ laughter ] gene the machine, they call me. >> jimmy: oh. >> 985427. >> jimmy: gene, before you finish, are you all by yourself there? >> oh, no, jimmy, i've got the secretary of state, gary belcher, by my side. come on in here, gary. >> jimmy: oh, wow. >> gary, gee. listen. >> jimmy: wow. hi, gary. gene, when do you think you guys will be finished with this count? >> good question. right about now i'm just about wrapping up the 2000 election. >> jimmy: oh. [ laughter ] >> we got a little behind on that. and then it's -- next up is the 2001 teen choice awards. [ laughter ] >> jimmy: oh, wow, you're still c

they knocked out every gene in the cell one by one. that's a lot of gene knockouts. you can imagine how many months or years that would take using normal methods. then looked at things like how quickly did the cells expand. did they expand faster or maybe maybe they looked at a lot of other markers. what came of this was they recapitulated in a week 30 years of work that had been done by the leading immunologist in the told. people who started their work people who started their work hiv hiv in the '80s or previous to that and had discovered all of these things like immune checkpoint inhibitors or checkpoints like foreign pd 1. these genes all popped up and they were able to find all of this stuff and you can bet that they found a bunch of new targets that no one had heard of because when you -- when you have an inflection point in the -- any given industry -- >> is this an inflection point right now? >> i think that's what makes it interesting to your original question, we are -- there's enough technologies coming together, we all know between sequencing is happenin

projects according indefensible a chinese research or tales of genetics conference why he edited the genes of twin baby girls. and relief from buying munich and their coach then in fact the champions league victory that trash bin three to five won by and have now booked a spot in the knockout stages of europe's top football tournament. i don't welcome. moscow has shrugged off suggestions by european officials that it could face fresh sanctions or the crimean crisis tensions escalated between moscow and kiev off to russia sees three ukrainian naval vessels in a skirmish on sunday at least a dozen sailors have been detained for trial ukraine's president has warned its neighbor is for a parent for war and has requested but for help. speaking on ukrainian state television president petro poroshenko said he turned to berlin after the kremlin failed to respond to his request for dialogue it was. immediately that night i ordered a phone conversation with the president of russia vladimir putin. we did not receive any response and i had to turn to the german chancellor so that she could talk to pro

those genes. early evidence that target two of more genes along with tandard immunotherapy it may prove beneficial and have her side effects. approved.f.d.a. you need more studies controlled, et cetera. carried out ey are they will be positive. , the first eard turned out to be negative. therapies and treatments and screening all abroad or are we in better position here? it is available globally. i think that the treatments may not be ay or depending on the country. radiationed countries is available and there are many not.tries where it is same for chemotherapy. we hope that people are able to treatment.iate >> developing countries still a challenge? >> it is. mentioned about 90% of cervical cancer deaths occur in developing world. way to think about it is that one woman in three who develops united cancer in the states will die from it. two women in three who develop developing world are going to die from it. nd many more in the developing world will get it. asically a quarter million women perr

of gene editing, even if one did do it.t suffer from x, y and z. it is not a case of creating designer babies, that is the claim. it is much often better to do something that is well established and regulators, which is preimplantation diagnosis, when embryos to parents, you select which one of those will be healthy, that way you don't change anything, but you still look for healthy children. it is actually quite rare and complicated to think of a situation where editing healthy parents‘ dna would be beneficial. there is an argument here, but it is not a very good argument, that the deletion they did which makes them more resista nt to they did which makes them more resistant to hiv, but makes them far more susceptible for example to the flu is a good idea. so outlined where we are on the legal point of view, because people coming in will have their own ethical decisions and judgements, but where does the law stand around the world? so the uk in particular has a very good regulatory framework, the human embryo fertilisation

out of an embryo so though cell in my body has that gene that gene in the case of what dr he did he took out a gene that enables you to get into the. cells that you're exposed with that same gene could be involved let's say in the proper functioning of the brain or the liver or the heart and so one of the concerns with this technology is that if we take out a particular gene because we think it may be involved in a particular disease or or function might that gene have other functions that we don't yet fully understand that may lead to problems of the child. hello again the headlines on al-jazeera the white house says it's unlikely the u.s. president will meet the saudi crown prince during the upcoming g. twenty summit in argentina because of his busy schedule this comes as the senate is there to be briefed on wednesday about the ongoing u.s. involvement in the war in yemen and the murder of journalist john. the head of the cia and you know hospital has listen to recordings of cautions death but reportedly won't be at the briefing mike hanna has more from washington. well there's be

he said to use the gene editing tool called crisper to delete a gene that makes people vulnerable toor of the crisper gene editing tool watched him speak. >> we still need to understand the motivation for the study and what the process was for informed consent. >> reporter: all the couples involved in the study consented he said and seven couples are involved in the study, all of the fathers are hiv-positive and the mothers are hiv negative. experts say some of the risks with this gene editing is the possibility of contracting other viruses such as west nile. >> the technology is not mature enough. >> reporter: dana carol a professor of bio chemistry is worried about how the study will affect other research. >> we want to make reproductive editing available for those with devastating diseases. i hope this doesn't send us backwards. >> reporter: he jiankui claims he paid for all the treatment himself . the second potentially pregnant woman is being monitored closely. >>> it's going to be a stormy night throughout the bay area. the radar is getting more active before the storm. coming

gene talked about the watch.e got excited about that wind chill for apple health care don't we. >> this is a different issue than how they report. >> why bother with that the stuff? you're right the phone is the most important but the entire product line it's important to understand what's what. >> apple is close to after hour session lows much more on apple during the show. we continue monitoring the comments from the conference call and check in on earnings movers heading to break. look at starbucks. soaring while akshe shack is sinking. trade after the market closes. it's true. so all... evening long. ooh, so close. yes, but also all... night through its entirety. dg come on, all... the time from sunset to sunrise. right. but you can trade... from, from... from darkness to light. ♪ stocks when "fast money" returns. >>> a and we continue to the monitor in precipitous drop after the cfo says they will no longer provide unit sales figure for the iphone, mac and ipad with the decline in the after hours session app

, we don't know how that gene is going to influence any other diseases.le think that gene also can influence your risk for west nile virus and make you more susceptible to other diseases. whether it is going to affect like any other like disease susceptibility, we still don't know yet. emily: jiwoo, the chinese national health commission is investigating. and drew, tell us a little bit more about the chinese government's reaction here because officials are not happy. drew: no, they are not. we are still seeing that reaction play out. right now we have seen the chinese health officials say they have put a stop to his research. he was he pulled out of a , conference where he was supposed to speak in hong kong. and the there have been officials saying that what he did appears to have been illegal potentially, and there appeared to be some issues where his university where he was working at in shenzhen said there may have been some signatures forged on permission documents for the university's ethical committee. so i think we are going to see this continue to

one way of doing that is thinking about the genes and try and to target those genes. there is evidence involved in towing that if you target loose jeans along with more standard immunotherapy, that this may actually prove beneficial and may have lower side effects. it's not yet fda approved. you need to do more studies. we hope if the studies are carried out, they'll be positive. we heard that the first effort we heard that the first effort turned turned out to be negative. is the vaccine available abroad? >> it is available globally. i think that the treatments themselves may ore may not be -- or may not be available depending on the but in but in developed countries, you know, radiation is therapy. there are still many, many countries where it's not. the same thing goes for chemotherap there there is a w.h.o. list with chemotherapies so we hope that people are able to get the propose therapy. >> so developing countries it's still a big challenge. >> it is. low and middle income companies. >> as mentioned, you know, about 90% of cervical cancers deaths occur in the d

. >> china halting a controversial gene editing program in its tracks. we will have more on that story coming up. >>> we all know the bay area is home to great chefs but there is a female chef in san francisco above the rest. how she is making history in more ways than one. >>> good morning. you can see traffic is moving along well to start the morning. a big difference from yesterday. so far so good on the ridges. >>> a little bit of a break but will not be sunny. it will be partly cloudy. one more system to deal with. we will take a look at that land of blue jeans. and burgers. and while blue jeans got all skinny on us... i can't feel my legs. ...no way are we giving up on burgers. that's why i created the all-american ribeye burger, made with 100% ribeye beef, ribeye burgers are back, america. try my all-american made with 100% ribeye beef fresh spring mix, and provolone cheese on a potato bun. it's a burger as american as bald eagles. i get it, i'm bald. fast food's first and only ribeye burgers are back, america. try them today. >>> welcome back. we

he said he used a gene editing technique to alter a gene in a pair of embryos before they were implanted into the mother's womb. >> the doctor hasn't offered proof but experts say it is entirely possible that he has done that. all of it is raising ethical questions about designer babies. s expert. spoke with a medical >> reporter: he the chinese researcher says he altered the dna of the twin girls to make them resistant to hiv. many scientists say he may have broken ethics rules.>> reporter: a chinese researcher is championing a medical breakthrough, claiming he has created the first genetic le edited babies. he says the twins were born healthy. he made the announcement on youtube saying he used a controversial gene editing technique to protect the babies from future hiv infection. seven couples took part in the fertility treatments. all the potential fathers had hiv and the mothers did not. >> someone has gone and done it. >> reporter: a biology professor at santa clara university who specializes in ethics teaches the techniques to research students using models of organism. if the clai

it is different than gene editing? . >> you are probably thinking about like christopher has so many different applications depending on what you are trying to do. the original help is you could fix or remove or do germ lines or to modify the unborn baby with a genetic defect to fix those defects in order to restore function that's where most of the conversation has been but the fact is still relies on things like viral vectors to make it slow and we have had some major breakthroughs in the last 90 days. so one of the papers is unpublished i can get into much to it but it is coming out soon but i will give you the high level anybody sophisticated can fill in the blanks. the high level is you can use whatever technology you want just to push it into a cell and now for the first time make a cut and insert a very large amount of dna this was published six months ago whenever it came out and we have shown you can insert an entirely new t cell receptor at 1500 base of dna into a cell without killing it or harming it or mess

critics are calling indefensible a chinese researcher towns of genetics conference why he edited the genes of the twin baby. i'm on the thought she most school has strong suggestions by european officials that it could face fresh sanctions over the crimean crisis that tensions escalated between moscow and kiev after russia seized three ukrainian naval vessels in a skirmish on sunday at least a dozen seat as have been detained for trial ukraine's president has warned its naval its preparing for war and has requested billions help. speaking on ukrainian state television president petro poroshenko said he turned to berlin after the kremlin failed to respond to his request for dialogue it was. immediately that night i ordered a phone conversation with the president of russia vladimir putin. we did not receive any response and i had to turn to the german chancellor so that she could talk to put on the immediate release of ukrainian servicemen and ukrainian ships. poroshenko also said the authorities would take all necessary steps to release the ukrainian sailors detained on sunday when russia c

out of an embryo still no cell in my body has that gene that gene in the case of what dr he did he tookout a gene that enables a try to get into the bar of the cells that you're exposed hit me with that same gene could be involved let's say in the proper functioning of the brain or the liver or the heart.

edited, and could pass these gene at its on to babies.ot like ticking sells out and sticking them back in. this could be passed on, so it is controversial. youtube: it was done on , when i thought youtube wasn't accessible in china. what about the ramifications for u.s. stocks that moved on this? editingseveral gene companies were up today. it is unclear why they went up. are notntist's claims what they are trying to do. they are trying to do something , working on diseases like sickle cell and they are talking about modifying adult cells, not permanent gene editing of embryos, which is a whole mother level of controversy. level ofe nother controversy. joe: the u.s. has restricted -- >> the u.s. restricted some of this research, unlike china which has given it more of a green light. what kind of regulatory issues are there? : one of the ethicists i talked to says there hasn't been a lot of global agreement or attempts at global agreement, like, what will we do about these powerful technologies? the laboratory kits can cost less than $1000

it's called a crisper gene editing.this dna heals itself. whatever this gene codes for, a disease, a condition in theory, maybe even other things like hair color, is now gone. >> what are the possible benefits of this usage? >> well, the excitement about this, robin, is that it can be used to treatment deadly diseases that are inherited so it's being studied for cystic fibrosis, even for cataracts. the question here is whether you can use it for other things and what those things will be. it's actually being studied intensively for use in food and agriculture to make certain products less susceptible to viruses and that kind of thing. >> so, let's talk about the risks and the ethical debate. >> the risks, when you talk about this, you have to understand this is not perfect. there can be inaccuracy. it can miss the target. if you take a gene out, future generations can be affected and then you could wind up with a situation where you have a lot of people with a disability or not a disability and is there a result in stig

because if you have a brown-eye gene and a blue-eye gene, you're going to get browon eyes. or cystic fibrosis is recessive, or diabetes or many, and it takes up to 20 generations for recessive mutations to express themselves. so we're talking about eons of timeme for expression of genetic disease--that's the second thing. the third thing is if the man's got plutonium in his testicles--and every mamale in e northern hemisphere has a tiny load in his gonad--it's from weapons testing days, and plutonium i is still falllling . and the man is cremated,d, the smoke goes up the e chimney with the plutonium,m, so you can breathe it in, another man can, and it's ad infinitum because plutonium has a half-life of 24,400 years and laststs for a long time. but the other thing is that thee body thinks plutonium is iroron--it's an irn analogue--so it's stored in the liver, where it causes liver cancer. it's stored in the bone marrow to cause--to produce hemoglobin in the red blood cells, but it causes leukemia or bone cancer. it crosses the placenta into the developing embryo--which lets

loup ventures' gene munster. gene: surprisingly, it is not alarming. want to put it into some context historical context. , the supply chain, when there --when there is early feedback, it is still early in the quarter, these tend not to be good indicators. the reason is that apple already gave their guidance on november 1. so two weeks in, we are hearing my chain cuts. it is not alarming because what we are hearing from the suppliers you mentioned is that those comments were already reflected in apple's guidance, so there should not be anything new. in my history on trying to figure out the supply chain data points is this is clearly more an art than a science. one thing that is important to know is every year, going into a cycle, apple tells their suppliers they need to produce more than they will actually have orders or. and every year, the cut orders going into this period. so this is nothing new. emily: shares have come back a bit, but in general, how confident are you that the latest lineup of iphones has been a hit? or is that not the question to