. >> reporter: both herceptin and perjeta developed at genentech. they point out the therapy isn't new to most doctors but the clinical trial showing its effectiveness is. the findings were published in the new england journal of medicine. >> the study is really the result of many years of reserve here and in fact about 30 years. in really trying to understand what drives a subset of breast cancers. >> reporter: the drugs may not be for everybody. costs about 11,000 a month, insurance companies cover some patients, and genentech has a program to help people who can't afford. for michelle, tumors and lesions disappeared. she'll continue treatment under doctors' orders and says it's been life changing. >> it's been a year and a half. so far, so far it's been great. >> reporter: ian cole, nbc bay area news. >>> 7:18. let's check in with anthony slaughter with a look at our weekend forecast. >> cloudy in the south bay now but we have lots of sunshine across the rest of the bay. it's one of those days where you get sun, cloud, rain, and sun comes back ou

the combination includes two drugs made to go together by south san francisco-based genentech. researchers gave the combo to 800 patients with hard-to-treat types of breast cancer usually considered a death sentence. on average the patients lived more than a year longer than with one treatment alone. >>> millions of americans braved extreme cold overnight and more frigid temperatures are on the way. niagara falls in upstate new york completely frozen. in maine a record 109 inches of snow over the past three weeks has roofers working overtime. record lows are forecast across the region this morning as well. here are just a few. lexington, kentucky, minus 12 degrees. nashville, tennessee, minus 2, just a cold grip going on many parts of the country. >> it just seems, it's amazing how starkly different both coasts are. >> yes. urjz the better side of that, and christina of course always delivering the good 8.n. you said there's damp conditions out there this morning. >> a little mist and drizzle on a friday eve. we're waking up in the 50s so a warmer start than what a lot of the

combination includes two drugs practice to go together by california based genentech and plus standardhemotherapy drug. doctors say will is good news with some with the deadliest form of the disease. breast cancer is the bigger killer of american women after lung cancer. >>> when it comes getting your nails done it's not about the pretty polish. there is a potential for infection. varnish lane is the first salon to offer waterless mani/pedis. the owner came up with the idea after visiting california. eliminating the water may reduce health risks but health officials say infections can still happen anywhere. we've post continues on how to tell whether your nail salon is safe nbcwashington.com, search nail salon. >>> want to head right into the "weather center" and tom kierein. >> it is dangerously cold with windchills right now got to respect the cold cover your extreme i dids. wear your p warmest winter gear this morning. we have the winds grusing 15 to 20 miles per hour. windchills between now and 8:00 will be around minus 5 to minus 10. later this afternoon, generally around 0 to min

from the california department of public health, daycares associated with oracle, gilead sciences, genentech all have 100% compliance. and electronic arts and yahoo! are very close. >>> just into our newsroom this morning expedia is buying orbitz. we continue to see consolidation here. expedia bought travelocity about a month ago, and already owns hot wire and hotels.com. just out of curiosity, sam and laura, i ran a couple searches through that search engine for next weekend. i did it through a budget travel site including expedia and orbitz. i came up with the same rate no matter what. so less competition but i think the hotels have long caught onto this and you'll see pretty much the same price no matter what you use. >> thank you very much. >> still like to dig for these deals if you can. >>> starting today a san francisco school is putting itself in a tech time-out. >> it's kind of a new national thing. for the next three days students at convent and stute hall will voluntarily be shutting off their electronic devices. that school is the first the bay area and the third in the entire st

according to the data, daycares associated with oracle, gilead sciences, genentech have 100% complianceectronic arts and yahoo! are very, very close. it's ban lot of years since i had kids in daycare, but the data is super easy to use. for campbell parents, 95%. you can look it up yourself and your daycare. >>> let's check the markets. landon dowdy is live at cnbc world headquarters. good morning. >> good morning. the markets will look to push higher today after a mixed close on wednesday. echoing gains in europe as investigators cheer a peace deal reached today between russia and ukraine. unemployment, retail sales, and earnings today from kellogg and kraft foods. >> landon, thank you. amy pascal, former head of sony pictures, was in san francisco yesterday for a conference on women which she joked on stage she'd been surrounded by successful people while all she got is fired. e-mails prove to be embarrassing. she paid women less than men, case in point, superstar jennifer lawrence, co-o which the hollywood reporter said pascal explained, i run a business. people who want to work for l