fergus walsh, bbc news. laura: for more on the significance of the trial we are joined now by dr. carla wish. welcome to the program. just how much of a benefit do you think that this drug could be forlzheimer's patients? >> scientifically it's quite significant. compared to all existing treatments, this is a drug with an entirely different mechanism. already it shows patient cognition and function and other measures of well-being were improved, but what's even more exciting is the drug produced changes on the biological measures of alzheimer's. in the amyloid that was cleared. what's more exciting is that the measures of the disease were done with blood tests. presenting enoous efficiencies and conveniences for protecting the disease and potentially for monitoring response to the drug. so this is reallexciting. it's a scientific breakthrough and a clinical breakthrough. laura: however how long could it be before patients see the benefit of the drug? >> well in my country the united states we have to go through a regulatory review with the food and drug administration. let's assum

fergus walsh, bbc news. on the bbc. still to come on the programme. the best thing since sliced bread — why the humble french baguette has been given unesco heritage status. it's quite clear that the worst victims of this disaster are the poor people living in the slums which have sprung up around the factory. i'm feeling so helpless that the children are dying in front of me and i can't do anything. charles manson is the mystical leader of the hippie cult suspected of killing sharon tate and at least six other people in los angeles. at 11am this morning, just half a metre of rock separated - britain from continental europe _ it took the drills just i a few moments to cut through the final obstacle. then philippe cozette, a miner| from calais, was shaking hands and exchanging flags| with robert fagg, his opposite number from dover. this is newsday on the bbc. i'm in singapore. our headlines. buckingham palace issues a formal apology — as a senior member of the royal household is accused of making racist rema

here's our medical editor fergus walsh.s to let rip across and under immunised population with little natural immunity. that has worried neighbouring countries including japan, south korea and india who have imposed covid checks on arrivals from china. the us has followed suit saying a lack of adequate and transparent data from china was a part of the decision to require a negative covid test. italy is the only european country to impose checks, including a post arrival pcr test which will allow genomic surveillance of potential new covid threats. the outbreak in china is being driven by several 0micron sub variants including bf7 which has been circulating in the uk. the latest estimates for the uk this month way that one in 45 people had the virus. that probably means 1 people had the virus. that probably means1 million people a week i getting infected so there is plenty of covid around here. but most of the uk population is very well protected from severe illness via a combination of vaccines and repeated natural infectio

paramedical editor, fergus walsh, there are.tia 3—0. lionel messi scored the first goal in the 34th minute. 0ur sports presenter, 0lly foster, is in doha with all the details. the smile on lionel messi's face at full—time at the lusail stadium was as wide as the doha corniche behind me. yet again, the argentina captain instrumental in everything they did here, carrying his country through to a sixth world cup final. it was julian alvarez, his strike partner, fouled after the half—hour mark against croatia, it was messi who stepped up to score the penalty, his 11th world cup goal for argentina, overtaking the old mark of gabriel batistuta. he is up to five in qatar and level in the race for the golden boot alongside kylian mbappe. alvarez ran at the heart of the croatian defence before halftime, got the luck of the bounce, but hit their second from close range, 2—0 at halftime and lionel messi weaved his magic on the right with 20 minutes left of play, turning one croatian defender and another inside and out before finding alvare

fergus walsh, bbc news.xpected to arrive back in the country later today, after their 2—1 world cup quarterfinal defeat against france in qatar. the reigning champions will now face morocco for a place in the final. let's speak to our sports reporter, john watson who's in qatar. j°y joy for france but what went wrong for england? joy for france but what went wrong for england?— for england? that is the age-old auestion for england? that is the age-old question when _ for england? that is the age-old question when it _ for england? that is the age-old question when it comes - for england? that is the age-old question when it comes to - for england? that is the age-old i question when it comes to england for england? that is the age-old - question when it comes to england in a knockout matches at major tournaments. you can't fault the performance as has been the case in the past, the call has always been vigorous south gate and the players he has at his disposal to play a more attacking style of football and g

fergus, many thanks, fergus walsh, there.to an icy lake in solihull, has been named. jackjohnson was pulled from the water at babbs mill park on sunday, along with an 11—year—old boy and an eight—year—old. another boy, who's six, remains critically ill in hospital. our midlands correspondent phil mackie has the latest. for a third day, police have been searching the lake. they say they no longer think anyone is missing, but they have to be sure. if anything, the ice has spread even further after temperatures plunged again overnight. ten—year—old jackjohnson was one of the three who died. today, his school was back open after an impossibly difficult 2a hours. one of the boys was in my daughter's class, and we told her yesterday, and it was really heartbreaking. we all went to get some flowers, and it kind of eased her pain, and there is a sense of community spirit, so, you know, it's just tragic. really tragic. the grief is still clearly visible. after school, many of jack's friends brought flowers to add to the growing mass o

fergus walsh, bbc news. the pacific after a three—week test mission. it captured images like this — looking back towards earth. 0ur science editor rebecca morelle reports on the end of a key stage of an ambitious programme. after a million mile journey through space, it's time for the orion spacecraft to come home. with images taken from the capsule, it enters the earth's atmosphere. the spacecraft about to go subsonic. a series of parachutes open... and there it is, high over the pacific, america's new ticket to ride to the moon and beyond now in view. ..then splashdown — the artemis mission is complete. the latest chapter of nasa's journey to the moon comes to a close. we are adventurers. we are explorers. we always have a frontier, and that frontier is now to continue exploring the heavens. and lift off of artemis i! the mission blasted off in november and over the course of 26 days, it captured stunning images of the lunar surface and flew far beyond the moon — further than any spacecraft built for human

with more, here's our medical editor fergus walsh.y now but used to be unable to walk as a result of a rare genetic condition. it took his parents years to get a diagnosis and the medicine he needed. i diagnosis and the medicine he needed. .,, diagnosis and the medicine he needed. _, ., diagnosis and the medicine he needed. ., ., needed. i lost count of how many doctors _ needed. i lost count of how many doctors and - needed. i lost count of how many doctors and consults| needed. i lost count of how. many doctors and consults we went to see and how many tests they did on him. forfollowing a half years the doctors could not tell us really what to expect. not tell us really what to exect. . not tell us really what to meet-— not tell us really what to exect. ., ., . __ expect. that diagnostic odyssey onl and expect. that diagnostic odyssey only and that — expect. that diagnostic odyssey only and that when _ expect. that diagnostic odyssey only and that when i _ expect. that diagnostic odyssey only and that when i when's - expect. that di

fergus walsh, bbc news.at least three people died have said they no longer expect to find anyone else alive. specialist teams who spent the night combing the wreckage in st helier said their mission was now a "recovery operation". there are reports the authorities had been warned of a gas leak the day before. 0ur correspondent danjohnson is on the island says more details about events prior to the explosion are being confirmed. those reports of a fire service attendance at this block of flats on friday have been confirmed by the authorities here on the island, that residents smelled gas, were concerned, called the emergency services and the fire crew did attend that building at about 8:30pm on friday night. now, they've not given any more detail of exactly what checks took place, what action occurred, but the fire crew left that building, presumably declared it safe. no further action was taken, as far as we know. but then, the next morning at 4:00am, there was this huge explosion which completely destroyed

fergus walsh, bbc news.s that paul whelan won't be freed in time to see his ageing parents. over its deal to return us basketball star brittney griner to the united states. they argue the prisoner swap was a bad deal with russia. the bbc�*s azadeh moshiri explains. what is your mood? happy! happy? relief for basketball star brittney griner but to bring her home, the white house gave in to some of russia's demands. that included leaving former us marine paul whelan behind. he was sentenced to 16 years in prison in 2018 on spying charges. there have been disappointments in the past. i think this one maybe struck us a little bit harder as we'd been expecting, based on the state department's statements about a substantial offer being made to the russian government, that paul would be coming home. the white house, the biden administration, has been much more open about what has been going on, and that's helpful to detainees' families. there's still a lot that goes on behind the scenes, so we might not know until

fergus walsh, bbc news.osecutors say a libyan man who is accused of making the bomb which destroyed pan am flight 103 over lockerbie is in united states custody. the bombing attack in december 1988 killed 270 people. let's get more on this from bbc scotland's home affairs correspondent david cowan. good to talk to you. tell us a little bit more about why the americans are pursuing this man and what exactly they are accusing him of having done. fin of having done. on the 32nd anniversary of— of having done. on the 32nd anniversary of the _ of having done. on the 32nd anniversary of the lockerbie| of having done. on the 32nd - anniversary of the lockerbie bombing in 2020 the outgoing us general attorney william barr announced charges against abu agila masud, the american said abu agila masud had confessed to making the bomb which was smuggled onto a plane in malta, then transferred onto another plane in frankfurt and ultimately transferred onto the plane at heathrow. it is an exploded into the skies over locker

fergus walsh, bbc news.out the conditions — warnings which many walkers disregard. jonathan swingler reports. the hills are definitely a lot busier and we are seeing a lot more things that make us wince. seeing something on social media does not necessarily give a whole picture of what it is like to get to that place, what the conditions could be like when they get there and what could happen if it actually goes wrong. every day from now until easter, the fell top assessors head up helvellyn. we�*re not fell top policeman, but we are providing information to give people information to keep them safe on the fells. it is very deceptive as well, when we set off today from the car park, you can see the tops of the hills, you could see there quite clearly, then we come up here and you look around here, the cloud is very low and the summits themselves are all in the clouds. unfortunately, 2021 was a record—breaking year. the mountain rescue teams were called out almost 700 times. i think it�*s going to get worse b

fergus walsh, bbc news.ncy nasa, the us space agency nasa has announced its uncrewed 0rion capsule has successfully returned to earth. it splashed down in the pacific ocean, ending its three—week test mission around the moon. if everything has gone to plan, engineers could decide that the vessel is ready to take astronauts back to the moon later this decade. england's footballers are on their way home after being knocked out of the world cup in a match against france watched on tv by more than 20 million people in the uk. members of the team have been saying it will take time to come to terms with the end of this world cup dream — and thanked fans for their support. our sports editor dan roan reports from doha. out of the tournament they believed they could win, england's dejected players left their al wakrah hotel earlier than they'd hoped this morning. the journey home accompanied by all—too—familiar thoughts of what might have been. commentator: he's missed it! the moment that will haunt harry kane. this

fergus walsh, bbc news.mulkerrins. england are on their way home from qatar after they were knocked out of the tournament last night, captain harry kane says that they will be mentally and physically stronger for the next challenge while manager gareth southgate he says he will review and reflect. let's head live to 0lly foster who is in doha for us. i wonder what's reflections the england team will be thinking about, experiencing today as the hours move on from that initial heartbreak last night? i on from that initial heartbreak last niuht? ~' , night? i think when we spoke in the last hour you _ night? i think when we spoke in the last hour you asked _ night? i think when we spoke in the last hour you asked me _ night? i think when we spoke in the last hour you asked me the - last hour you asked me the atmosphere around the place now from an england perspective, used the word flat. england are actually released one of their in—house videos, and interview gareth southgate gave this morning, before they lef

fergus walsh, bbc news.stroyed a block of flats on saturday. three bodies have been found so far. there were at least nine known residents at the time of the blast, but authorities say as many as twelve could have been killed, as the number of visitors is not clear. the bbc�*s meghan 0wen reports. candles to mark the lives of those lost, and hope for those still missing. the explosion had funded over st helier in the early hours of yesterday morning stop emergency services were at the scene within minutes. they found a three story block of flats completely flattened. it is a scene of utter devastation. i mean, the building has completely collapsed. it is, it is that it doesn�*t even look like a building was. smoke stained the skyline of st helier as fire crews helped people from neighbouring buildings. we heard an explosion about four o'clock this morning, 3:30am or4z30am. we got up, we found that in our flat, all the windows had been put in, the staircase had been damaged. and there was fire everywhere. all

fergus walsh, bbc news. customers of billions of dollars. ftx was the world's second largest crypto exchange — allowing customers to buy and sell cryptocurrencies such as bitcoin. the us securities and exchange commission allege he misused funds belonging to its trading customers. joe tidy has more. sam bankman—fried was the front man of his $32 billion ftx empire. nicknamed the king of crypto, he was one of the industry's biggest personalities. but since his empire collapsed leaving more than1 million customers out of pocket, he has faced numerous accusations of misusing customer funds. has faced numerous accusations of misusing customerfunds. now in custody in the bahamas, the us accuses him of, in their words, building a house of cards on a foundation of deception. in multiple interviews most recently with the bbc this week, he admitted to mismanaging ftx.— bbc this week, he admitted to mismanaging ftx. where you or fraudulent? _ mismanaging ftx. where you or fraudulent? i— mismanaging ftx. where you or f

fergus walsh, bbc news.— fergus walsh, bbc news. that is amazini. fergus walsh, bbc news.n through. whatever you do for a job, we sit here and talk out loud sitting on a sofa, some peoplejust do here and talk out loud sitting on a sofa, some people just do amazing things, don't they? though scientists, just incredible. scientists, 'ust incredible. thank ou to scientists, just incredible. thank you to elise _ scientists, just incredible. thank you to elise and _ scientists, just incredible. thank you to elise and family _ scientists, just incredible. thank you to elise and family speaking| scientists, just incredible. thank i you to elise and family speaking to us. later in the programme, we'll be joined by dr rob chiesa, consultant in paediatric bone marrow transplantation, who has been involved in the trial. that's coming up at 08:35. let's have a look at the papers. 6:25am. there's one story that dominates the front pages today. it kicked off at seven, it was all done and dusted by nine, it had time to make the front pages of the papers, which is not always the case with

our medical editor fergus walsh says a description of this as a breakthrough is justified. it is an imperfect drug, has modest benefits, and is only benefiting those in the early stages of the disease, but it is proving can support that alzheimer's can be tackled, can be slowed, a bit like when we had the earliest drugs for hiv. they weren't terribly good, but better drugs. there is more than 100 alzheimer's treatments in trials, and entually we will see this may be being used in combination with other treatments that tackle another rogue protein that attacks the brain. we are going to need a revolution in diagnostics if we are to identify patients in the early stages of alzheimer's, because at the moment only 1% or 2% of patients who are given a diagnosis of dementia have those tests to confirm that they have the presence of amyloid in their brain. maryam: stay with us on "outside so," because still to come, the islamic state group has announced the death of its leader. the u.s. military says he was killed by rebels in southern syria. >> it is quite clear that the worst vic

which was first developed in the moderna and pfizer coronavirus vaccines. 0ur medical editor, fergus walshf preventing disease, but this is a personalised treatment for patients with cancer, using messenger mrna technology that was first used in some covid jabs. it works like this. a sample of the patient�*s tumour is analysed, and dozens of mutations unique to their cancer are identified. the vaccine contains strands of mrna which give coded instructions to cells to produce the rogue proteins from the tumour. this stimulates the patient�*s immune system to attack their cancer. in effect, the vaccine unmasks the cancer cells, which until then had remained hidden. the trial involved 157 patients with melanoma, the most serious form of skin cancer. the companies involved say the results are promising. it's the first randomised trial testing an mrna theraputic in cancer patients. it has shown a 44% reduction in the risk of dying of cancer or having your cancer progress. that's an important finding. and i think it has the potential to be a new paradigm in the treatment of cancer patients. the

fergus walsh, bbc news.week test mission around the moon. the unmanned capsule will splash down in the pacific ocean off the coast of california. if it goes smoothly, engineers could determine that it's ready to take astronauts back to moon later this decade. this is the live scene at nasa hq. this is the live scene at nasa hq. this is the live scene at nasa hq. this is a live feed at nasa where we are expecting that splashdown in the next minutes. while we are waiting that, we will take you to it life when it happens, but let's speak to elizabeth pearson, the features editor of the sky at night magazine. i'm excited about this. how are you feeling with just minutes to go? very exciting. this is something we have been looking forward to for years. this mission has been delayed a couple of times at the very last minute. to finally see that it is about to reach its completion, because this is one of the most important faces that are to miss one is going to make share it can bring people back to earth safely. i

here's our medical editor, fergus walsh.unised population with little natural immunity. that's worried neighbouring countries, including japan, south korea and india, who've imposed covid checks on arrivals from china. the us has followed suit, saying a lack of "adequate and transparent" data from china was partly behind its decision to require a negative covid test. italy is the only european country to impose checks, including a post—arrival pcr test, which will allow genomic surveillance of potential new covid threats. the outbreak in china is being driven by several omicron sub—variants — including bf.7 — which has already been circulating in the uk. the latest covid estimates for the uk earlier this month were that around one in 45 people had the virus. that probably means a million people a week are getting infected, so there is plenty of covid about. but most of the uk population is very well protected from severe illness via a combination of vaccines and repeated natural infection, meaning covid, while still a potent

which then attacked the cancer, and the teenage patient is now in remission. 0ur medical editor, fergus walshrd. the whole experience has brought me so much closer to my family. alyssa is back at home in leicester thanks to a pioneering new cancer therapy. all other treatment options for her leukaemia had failed. breathe in and breathe out. . thank you, that's a good one. so in may she received a world—first therapy. i know that i've helped other children as well, that other children might be able to get cured because of the research that i've been part in. it is extremely exciting, - so obviously this is a new field in medicine, and it's fascinatingl that we can redirect the immune system to fight cancer. alyssa's immune system couldn't clear her cancer, so she was given donor cells which had been tweaked using a new technique called base editing. in the lab, three precise changes were made to the cells' dna, and they were then armed to fight her cancer. base editing is part of a genetic revolution which is transforming our understanding of human biology. it is an incredibly precise tool wit

would be tailored to individual patients and their specific type of cancer. 0ur medical editor fergus walshd in some covid jabs. it works like this. a sample of the patient�*s tumour is analysed, and dozens of mutations unique to their cancer are identified. the vaccine contains strands of mrna — which give coded instructions to cells to produce the rogue proteins from the tumour. this stimulates the patient�*s immune system to attack their cancer. in effect, the vaccine unmasks the cancer cells, which until then had remained hidden. the trial involved 157 patients with melanoma, the most serious form of skin cancer. the companies involved say the results are promising. it's the first randomised trial testing — it's the first randomised trial testing that therapeutic and cancer patients— testing that therapeutic and cancer patients and shown a 44% reduction in the _ patients and shown a 44% reduction in the risk— patients and shown a 44% reduction in the risk of— patients and shown a 44% reduction in the risk of dying of cancer or having — in the risk of dying of cancer or having your— in t

our medical editor fergus walsh is here.s no evidence that we have a more virulent i it this year? there is no evidence i that we have a more virulent strain, cases of scarlet fever which are usually mild, and the more serious invasive group a strep where the bacteria gets into the bloodstream are higher than we have seen for many year, during the pandemic, where there was little social mixing we had almost no case, this is a contagious thing, hardly surprising we are seeing a resurgence. in april 2018 cases of scarlet fever were twice the level they are now, so we have seen big outbreaks before. iloathed have seen big outbreaks before. what about parents — have seen big outbreaks before. what about parents who _ have seen big outbreaks before. what about parents who want to get antibiotics for their child, to protect them? figs antibiotics for their child, to protect them?— antibiotics for their child, to protect them? antibiotics for their child, to irotect them? �* , ., , protect them? as we have seen in emma's report. — p

with more, here's our medical editor fergus walsh.he lottery, it was better than that, because we knew that there was a treatment pathway. we knew that we could get him support and he could attend a mainstream school with support, and have this full fulfilled life. it was incredible. she's not going to like this little bit. oh, yeah. this is how newborn screening is done now. the heel prick blood tests which this five—day old is having at the rosie maternity hospital in cambridge. it screens for nine genetic disorders, including cystic fibrosis. whole genome sequencing will identify around 200 conditions, all of them treatable. i think it sounds fantastic to catch babies that could potentially be ill a little bit later so early. the voluntary study will enrol 100,000 healthy newborns who will have their entire dna mapped, looking for gene disorders that emerge in early childhood. we could avoid harm that is done by picking those conditions up late and also reduce the pressure on families but also the health system. there is enormous p

fergus walsh, bbc news.even members have completed their national service. a warning — this report from katie silver contains some flash photography. from adulation to apprehension. jin, the oldest member of bts, has entered compulsory military service, breaking hearts across korea and around the world. he posted this photo of his newly acquired buzz cut. the caption, "it looks cuter than i expected." with south korea technically still at war with its northern neighbour, all able—bodied men are required to serve for at least 18 months and must enlist by the age of 28. last year the band was given a special exemption to defer their service for two years. officials said they increase the value of the national brand. but now, withjin reaching 30 years old, the time has come. it has left many wondering what the future holds for theirfavourite band and can it survive this hiatus? translation: it was a very active i group starting with jin and i am | aware that all the other members are going to do their military